The Women’s Health Initiative Randomized Controlled Dietary Modification Trial was designed to study a low-fat diet, a nutritional approach to prevention of chronic diseases
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چکیده
The Women’s Health Initiative Randomized Controlled Dietary Modification Trial was designed to study a low-fat diet, a nutritional approach to prevention of chronic diseases that was considered promising. The negative findings from the trial were both unexpected and disappointing to nutrition authorities. The authors’ public responses to the findings articulated an unwillingness to believe the finding that a low-fat diet did not prevent breast or colon cancer or heart disease. The negative results should stimulate work on alternate hypotheses, and reconsideration of the long-standing proscription against dietary fat.
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Cancer incidence and mortality during the intervention and postintervention periods of the Women's Health Initiative dietary modification trial.
BACKGROUND The Women's Health Initiative (WHI) low-fat (20% kcal) dietary modification (DM) trial (1993-2005) demonstrated a nonsignificant reduction in breast cancer, a nominally significant reduction in ovarian cancer, and no effect on other cancers (mean 8.3 years intervention). Consent to nonintervention follow-up was 83% (n = 37,858). This analysis was designed to assess postintervention c...
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The Dietary Modification (DM) component of the Women’s Health Initiative (WHI) is a randomized controlled evaluation of a low-fat diet that is high in fruits, vegetables, and grains. This low-fat dietary pattern is hypothesized to reduce the risk of breast and colorectal cancer and secondarily, coronary heart disease, in postmenopausal women. To test these hypotheses, 48,836 postmenopausal wome...
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The Women’s Health Initiative (WHI) Clinical Trial (CT) includes three overlapping components, each a randomized controlled comparison among women who were postmenopausal and 50 to 79 years of age at randomization. The dietary modification (DM) component randomly assigned 48,836 (target 48,000) eligible women to either a sustained low-fat eating pattern (40%) or self-selected dietary behavior (...
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